1 response

  1. Lelia H. Downs
    November 26, 2013

    Recent investigations have cited the compounds as having greater potency than the THC found in traditional cannabis products because of Spice and K2’s unregulated production. While the most popular route is to smoke a product such as Spice Gold, you can also find websites selling pure (powder form) JWH-018, JWH-250, etc. Natural cannabinoids (delta-9-tetrahydrocannabinol, or THC) and synthetic cannabinoids (over 100 identified so far, but the most popular being JWH-018, JWH-073, JWH-250, and CP 47,497 C8) act by binding to two types of nerve receptors known as CB1 and CB2. Both receptors are linked to proteins that regulate neurotransmitters. The cannabinoids bind to the receptors to activate them. A neurophysiology theory on the better potency of synthetic cannabinoids over natural marijuana is that the synthetic cannabinoids bind better and longer to the CB1 and CB2 receptors than does natural THC.

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