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What Is JWH?

Published by Ryan under Articles Posted on June 28th, 2011

The most common type of artificial cannabinoids, an active component of Cannabis Sativa, and other imitations, which prevents nausea and queasiness, by enticing a trigger in the brain for appetite, is found in the market as blended herbs that can be smoked. These intermingled herbs can be found in stores, and multiple online shops. Despite of its legality, JWH is hindered by some legal holds, affecting some contents that can be found in JWH products.

Research on JWH compounds are very inadequate, on the contrary, a few compounds obtain an ample amount of information, compared to others. Development on imitation cannabinoids were conducted in the pre-1990 by a chemist, specializing in Organic Chemistry, named John W. Huffman. It was he who revealed and industrialized the compounds at Clemson University.

JWH is a trademark prefix indicating the crystalline compounds found in plants, and animals, also famously known as the indole family. The indole family comprise of the aminoalkylindole, and the napthoylindole unit. John W. Huffman’s primary goal was to develop a material that would zero-in on specific receptors in the body, also known as endocannabinoid receptors. The body is made up of two existing receptors, called CB1 and CB2 receptors. JWH chemicals portray the part of an agonist, a chemical that attaches itself to a cell receptor, and generates a feedback on that exact same cell. Further is a general view of the most popularly known JWH-XXX chemical composites.

Forms of JWH-XXX Chemical Compound and Description

JWH-015
The JWH-015 is an element of the Naphtyhoylindole Family. It plays as the “subtype-selective cannabinoids” agonist, also called as: (2-Methyl-1Propyl-1H-Indol-3-yl)-1-Naphthalenylmethanone. The said compounds’ resemblance to CB1 receptors is 383nM, contrary to its 12.8nM with CB2 receptors.
CB2 receptors has 28 times more similarity with JWH-015 than CB1, but conversely, some activity still exist with CB1 receptors. Epoxidation of the Naphtalene ring is a part of JWH-015. This is an effect that modifies a compound resulting to epoxide, which is cylic ether. Cylic ether has three-ring atoms that allow the epoxide to be extremely reactive. For familiarity’s sake, adhesives, origin from epoxy resins. Though minute research has been conducted, and surely, insufficient data is on hand, it is assumed that JWH-015 can manufacture carcinogenic movement.

JWH-018
This is also a chemical originating from the Napthoylindole Family. It is tagged as Naphthalen-1-yl-(1-pentylindol-3-yl)methanone or 1-pentyl-3-(1-naphthoyl)indole. In Herbal incense, JWH-018, is regularly found. It perseveres as a complete antagonist of CB1, likewise as with CB2 receptors.

Based on research, Tetrahydrocannabinol, or THC, found in cannabis, is five times weaker, in terms of affinity, if compared to CB1 receptors, and because of this, JWH-018, may result to ill consequences, such as: fretfulness, paranoia, shakiness, and fright episodes. As a result, JWH-018 is placed under a dissimilar category compared to the rest of the JWH compounds.
Similar to JW-015, it is also assumed that JWH-018, can make carcinogenic activity, however, there is no proof to this assumption to create a solid guilt.

JWH-073
A third chemical compound originating from the Napthoylindole Family, JWH-073 is called as Naphtalen-1-yl-(butylindol-3-yl)methanone. A semi-agonist to CB1 and CB2 receptors, the JWH-073 has been accused of being the root of psychological, and behavioral changes, in a user. A comparable outcome can be linked to delta-9-THC, found in animals. On the other hand, there is has been no concrete research done to see its effects on humans.

When binded to CB1 receptors, the JWH-073 has higher affinity, as compared to THC. To add, JWH-015, JWH-018 and JWH-073, are also presupposed to manufacture carcinogenic movement. Thus, caution is highly emphasized when dealing with these types of chemicals.

JWH-081
This compound is also known as 4-methoxynaphthalen-1-yl-1pentylindol-3-yl)methanone. It is the fourth in the Napthoylindole family. It also acts as an agonist in both CB1 and CB2 receptors. There is 10 times greater affinity in CB1 subtypes, as compared to CB2. The compound also bears naphthalene ring.

JWH-200
Aminoalkylindole family, is where JWH-200 belongs. The compound can also be identified as, (1-(2-morpholin-4-ylethyl)indol-3-yl)-naphthalen-1-ylmethanone, familiar also as WIN55,225. It proceeds as a cannabinoids receptor agonist to CB1. The affinity to CB1 receptors is 42nM, almost duplicate of THC. Nevertheless, JWH-200 contains three times more analgesic effect compared to THC, thus causing less sedation.

JWH-250
Also known as the last chemical in the Phenylacetylindole family, the JWH-250, is labeled as 2-(2-methoxyphenyl-)-1-(1-pentylindol-3-yl)ethanone. Like the above mentioned, it also portrays the role of an agonist of CB1, and CB2 receptors. 11nM is it’s affinity to CB1, and 233nM for CB2 receptors.

Prized as one of the latest compound in the unit, JWH-250, lacks the naphthalene ring due to its tendency to be utilized as a replacement for JWH-018, whenever the latter is banned.

The Aftermath of JWH-XXX Chemical Compounds
Regardless of its common root, JWH chemical compounds, respectively, obtain its own significant results on certain life form. Though it comes almost unnoticeable, and unique, these effects have various levels of potency. Level of potency can be categorized into two groups, the positive, and the negative.

The feeling of trance, jolly mood, sleepiness, leisure, happiness, creativity, unusual sensitivity, absence of time, and extreme sense of pleasure, needless to say, are the positive effects of the JWH-XXX. True enough, if there is good, there shall also be bad. The negative effects of the said chemical compound could be irritations, suspicions, red eye, dry mouth, and a noticeable surplus of appetite. The culprit for these negative side effects is the JWH-018. Per JWH user, the experience is similarly kin to the effects of THC.

JWH Measured Quantity, and Time Frame of Effect
Generally speaking, JWH employed in herbal blend goods, are extremely intoxicating, and substantial. The intoxicating effect allows a certain amount of activeness, but on a diminutive stage. There is no distinct, or significant, difference in the measured quantity amongst the six identified compounds, if there is, it is almost non-existent.

Measure quantity also varies the product is smoked, or consumed thru oral method. Little know how means of application can affect duration of impact in the body. Listed below is a distinct measurement of dose and lapse time of effects.

Mode of Utilization
Smokes or vaporized, both are the common ways of consuming JWH. Vaporized is the most favorable mode of utilization for it lessens the burning, dissemination, of active chemicals. Foil, aluminum foil, for that matter, is commonly used in vaporization. Wrapping the product in paper is most the most favorable way to smoke it. Chewing, is the way to go for oral distinction, however, this is the least recommended method. Whichever is declared, JWH users have their own respective way of utilizing their favored product.

To ensure the least amount of negative effects to reflect, warning sets in where in to precisely gauge the product before consumption, rather than assuming the right dose.

Overview of WIN Chemical Compound Families
Constant research is facilitated when studying the potency of the WIN Family of Cannabinoids. The said chemicals have been known to prevent inflammation, and tracks as painkillers. This chemical was developed for such reasons, stated above, in the 1980’s, and was called prostaglandin synthesis inhibitors.
There is limited research covering the WIN family. Reflecting below is a summary of the three most popular compounds of the family, alongside is a narrative of the nature of each, respectively.
Forms of WIN Chemical Compounds and Its Nature

WIN 55,212-2
This is a chemical referred also as aminoalkylindole derivative, also named as, R)-(+)-[2,3-Dihydro-5-methyl-3-(4-morpholinylmethyl)pyrrolo[1,2,3-de)-1,- 4-benzoxazin-6-yl]-1-napthalenylmethanone. It has been said to create same effects in cannabis, such as THC, but it must be pointed out that the chemical content is totally unique and unlike the other. WIN55,212-2 is a potent cannabinoid receptor agonist, with strong analgesic, or pain reliever effect, in rats.
The affinity is also more supreme for CB1 receptor agonist compared to THC. Studies show that this chemical can prevent soreness and swelling, caused by specific proteins, such as Amyloid beta proteins, present in persons suffering from Alzheimer ’s disease.

WIN 48,098
Referred to as Prayadoiline, this chemical was initially founded on the idea that it would serve as a fresh anti-inflammatory, and a prostaglandin synthesis inhibitor. On a later date, it has been shown that Prayadoline produces a maximum tolerance for pain, a strong analgesic. Doses were exhibited on smaller doses, ten times lesser, to be specific, showing that is a non-COX inhibitor. In addition, Prayadoline has been found to be toxic, therefore, it is no longer tagged as an analgesic.

Expounded studies reveal that WIN48,098 belongs to the synthetic cannabinoids family. This genius find, assisted the unraveling of the chemical compound WIN 55,212-2.

WIN 55,225
This is an analgesic, pain reliever, and pain killer, chemical. It belongs to the aminoalkylindole family, and roles as a cannabinoid receptor agonist. Affinity to CB1 receptor plays at 42nM, almost mimicking the affinity of THC, and is also known as JWH-200.

Expected Outcome of WIN Chemical Compounds
WIN 55,212-2 produces effects similar to the effects of THC, as research revealed. On the other hand, the effects of WIN chemicals have been accused of being less potent, and last for a shorter period of time. Numerous reports conclude that the effects are of same level as THC.

WIN Doses and Assumed Outcome
Contrast to JWH chemical compounds, WIN chemicals have less fluid information relating to its dose and assume outcome, or duration of effect. Upon oral method, or insufflations (inhalation), the measured quantity is geared between 1 to 3mg. The euphoria last between 1 to 3 hours.

Mode of Utilization
Insulation, at times, injection, but oral method is the most popular choice, when using WIN chemical compounds. Heat weakens the chemicals in these products, and so smoking these products create the least amount of impact, or desired result.
Warning: WIN chemical compounds require a greater terms of safety and precaution when using, contrary to JWH compounds.

Indication of CP Family Chemical Compounds

Pfizer first studied this family in the 1970’s. In spite of any developments on the study, Pfizer never published any information to the public. Surprisingly, it has been declared that CP compounds bear greater potency than THC, which is known to be stronger than JWH and WIN. So we can only imagine how powerful CP compounds are.

Researches done on Endocannabinoid uses CP chemicals nowadays, specifically those made by Pfizer, are assisting Scientist in studying the relationship between inflammation, and pain. Numerous CP chemicals have been manufactured by Pfizer, however, these chemicals do not all fall under the category of synthetic cannabinoids. Upon Pfizer’s discovery of the CP chemicals, it was then automatically pronounced as the first synthetic cannabinoids used in spice herbal blends between 2006 to 2008.

Limited amount of researches have been done on the CP family, so much like the JWH, and WIN chemical compounds. Listed underneath are common types of description for each CP chemical compound.

Kinds of CP Chemical Compounds and Its Narrative

CP 47,497
This is a man-made cannabinoids. The chemical also is directed under the alias of 2-[(1R,3S)-3-hydroxycyclohexyl]- 5-(2-methyloctan-2-yl)phenol, and grouped as a non-traditional cannabinoids receptor agonist. It has a strong affinity with CB1receptor, with Kd specifics of 2.1nM. It obtains analgesic characteristics. Its effect mimics that of the THC, but of a stronger version.

CP 47,497 C8
A well-liked member of its class, aliased as Cannabicyclohexanol, the dimethyloctyl homologue of CP 47,497, and is utilized as a vigorous ingredient in Spice blends, dating back in 2009. It has been publicized as a potent cannabinoid agonist, fashioning the properties of THC, to a higher level.

CP 55,940
Third compound of the family, tagged as 2-[(1R,2R,5R)-5-hydroxy-2-(3-hydroxypropyl) cyclohexyl]-5-(2-methyloctan-2-yl)phenol, and known as a highly potent, and non-classical cannabinoid agonist, as well. Contrary to THC, this chemical is 45 times more aggressive, and is a full agonist to CB1, and CB2 receptors. Subsequently, it also stands as an antagonist to CPR55, identified also as CB3 receptors.

CP 55,244
(2S,4S,4aS,6R,8aR)-6-(hydroxymethyl)-4-[2-hydroxy-4-(2-methyloctan-2-yl)phenyl]-1,2,3,4,4a,5,6,7,8,8a-decahydronaphthalen-2-ol, also renowned as the fourth chemical in this family. Extremely strong, and is also non-orthodox. It is potent, as much as it is a full agonist of CB1, and equipped with Ki of .21nM.

CP 50,556-1
An artificial cannabinoid analog, linked to the familiar medication called Dronabinol (Marinol). This chemical is also called Levonantradol, and has not been approved by the FDA. It was first developed by Pfizer. With strength weighing 30 times more than THC, it is highly potent. CP 50,556-1 also manufactures an anti-emetic property, thus helping to stop queasiness, or the feeling of vomiting once activated by CB1 and CB2 receptors. it also has analgesic properties.

Properties of CP Chemical Compounds
Limited details, coming from research, is divulged, in terms on just how effective this chemical is, however, there is enough data to prove that CP is much stronger, and more potent than THC. A user’s body weight, and dose taken, all collaborates on how the user will feel after administering the chemical into the body. Manifestations parallel to the feeling of bewilderment, massive stress of concentration, calm, and coolness. On the other hand, the negative outcome may switch from sleepiness, or lack of focus throughout the day of use, or even runs on through the next day.

CP Measured Quantity, and Aftermath of Use
Common users can consume as low as .25mg, and still manage to get the same desirable effect. On an average, the normal dose of users’ runs between 1 to 3 mg. Method of utilization may require different mg to obtain a desired result.

Scheme of Use
The apposite manner to consume CP is still up in the air, and has not been finished, and confined. Users have both smoked, and taken the chemical orally.

Warning: Toxicity of CP chemicals is still very much unclear, and unknown. There is not enough data to linger on its value and safety in use. Direct danger of this chemical is still a toss-up. Ample research must be conducted to suffice the question on its safety, and toxicity.

1 Comment » Posted on June 28th, 2011

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One Customer Review of “What Is JWH?”

Review by drew, September 5, 2011

just my two cents: there are so many negative things said about this that almost all new users are likely smoking it with negative bias and/or negative expectations which probably isn’t a good state of mind to be in when you are about to get high.

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